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العنوان
The Association of Factor V leiden, JAK2 Prothrombin and Methylene Tetrahydrofolate Reductase Mutations in Primary Budd – Chiari Syndrome in Egyptian Patients /
المؤلف
El-Shafey, Shiamaa El-Shafey Soliman.
هيئة الاعداد
باحث / شيماء الشافعى سليمان الشافعى
مشرف / حاتم محمود السباعى
مشرف / محمد علاء الدين نوح
مشرف / منال عبد العزوز سعفان
الموضوع
Human chromosome abnormalities.
تاريخ النشر
2015.
عدد الصفحات
179 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكيمياء الحيوية (الطبية)
الناشر
تاريخ الإجازة
15/6/2015
مكان الإجازة
جامعة المنوفية - كلية الطب - الكيمياء الحيوية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Budd-Chiari syndrome (BCS) is a clinical condition caused by hepatic venous outflow obstruction located anywhere from the small hepatic veins to the junction of the IVC and the right atrium regardless of the cause of the obstruction The etiology of BCS has been attributed to a variety of genetic and environmental factors while myeloproliferative neoplasm is considered to be the leading cause of BCS.
The aim of this study was to evaluate the association between factor V leiden, JAK2, prothrombin and MTHFR mutations and primary BCS syndrome.
This study was carried on 50 subjects, 35patients with1ry BCS and 15 age and gender matched healthy individuals were taken as a control group, they were 30 females and 20 males with age ranging from (18-50) years. The patients were attendants of BCS society and tropical medicine department, Menoufia University Hospitals .They were classified into the following 2 groups:
 Group 1: included 35 patients with BCS, 21 females (60%) and 14 males (40%) their ages ranged between 18 and 50 years.
 Group 2: included15 age & gender matched healthy subjects as controls. They were 9 females (60%) and 6 males (40%), their ages ranged between 18 and 50 years.`
Patients with either Tricuspid valve disease and/or congestive heart failure, primary and secondary malignant liver tumours were excluded by time of examination .