الفهرس 
DECLARATIONOnly 14 pages are availabe for public view
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Abstract
- Treatment of 3-hydrazonoindolin-2-one with the appropriate aromatic aldehyde and dialdehydes afforded a new series of mixed azines and the bis (azine) respectively. 2- The Mannich reaction with a new mixed azines was investigated as a possible route to mixed azines, related to 2-indolinone, having a potential basic side chain of alkaloidal nature. 3- The Mannich reaction of a new mixed azines with dialdehydes and formaldehyde led to the formation of the bis(Mannich basesvia a double Mannich reaction. 4- The 3-hydrazonoindolin-2-one was used in preparation of anew Schiff bases derived from N-amino-heterocyclesThe condensation of isatin with the appropriate N-amino-heterocycles used in synthesis of Schiff bases and its Mannich bases with an alkaloid partial structure. 5- The reaction of isatin with different hydrazides, hydrazides related to triazenes , bis(hydrazide) , a series of N-arylglycine hydrazides, hydrazono-bis(hydrazide), iminodiacetohydrazide and ethylenediamine-tetraacetohydrazide gave the corresponding hydrazide-hydrazones. 6- A similar reaction takes place with isatin Mannich base, yielding the corresponding hydrazide-hydrazones Mannich bases. 7- The amine components of isatin hydrazides was used in Mannich reaction with the Schiff bases of isatin to obtain anew Mannich bases related to isatin Schiff bases. 8- Reaction of the isatin hydrazide with aromatic aldehydes followed by the coupling with benzenediazonium chloride lead to the formation of isatin Schiff bases incorporating a formazan moiety as a structural unit. 9- The new Schiff bases incorporating a benzoylpiperidine, benzoylmorpholine and 1,4-dibezoylpiperazine moiety were obtained by treating isatin Schiff base with the appropriate heterocyclic amine. 10- The synthesized new compounds were screened for their preliminary antimicrobial activity against Gram-positive and Gram-negative bacteria as well as fungal strains.