الفهرس 
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Abstract
This study was carried out to evaluate the effect of administration of aspartame in two doses (40mg/kg and 80mg/kg body weight) on the submandibular and sublingual salivary glands of male albino rats. Ninety adult male rats weighing (200-250g) were used in this study. Animals were divided into 3 groups: Group I: composed of 30 rats and considered as control group. Group II: composed of 30 rats to be considered as experimental group 1 as rats were daily administrated APM (40mg/kg). Group III: composed of 30 rats to be considered as experimental group 2 as rats were daily administrated APM (80mg/kg). The histological examination of submandibular salivary gland sections of rats revealed serous acini to be distended and tended to be spaced with vacuolated cytoplasm. Nuclei showed signs of hyperchromatism. Most blood capillaries appeared to be engorged with red blood corpuscles. Striated ducts appeared dilated while granular ducts were stagnated. The sublingual gland of the same group presented normal morphological appearance in the first two months. Statistical analysis of PCNA immunoreactivity revealed significant increase in the area masked by the blue binary color from control group to the fourth month of the experiment in both glands and in both experimental groups. This index was found to be declined in the fifth and sixth months of the experiment.