الفهرس 
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Abstract
Liver disease is amajor public health problem and one of the leading causes of death nowadays . Hepatites C virus is the most common cause of liver disease which affects populations all over the world . Egypt has the highest prevelance of HCV infection with about half a million people get infected each year (Yahia, 2010).
One of the most important functions of the liver is processing , regulation and directing various hormones to perform their proper function in other parts of the body (Genes, 1977). So the consequence of liver disease especially hepatites C virus could be endocrine abnormalities.
Hormonal disturbance affect the sexual functions in both males and females that affect in turn the fertility of both sexes. Males with chronic HCV infection had markedly reduced sexual functions in all domains evaluated such as sex drive, erectile function, ejaculation and overall sexual satisfaction compared to HCV-free controls ( Dnoff et al., 2006).
Also HCV female patients might have higher estrogen levels and also may have abnormalities in progestrone metabolism ( Hanafi et al., 2011).
The aim of present work was to estimate the values if androstenedione , DHEA-S, testosterone and prolactin in HCV male patients and compare them with healthy controls .
The study includes 45 HCV male patients and 21 ages matched apparently healthy who served as control group.
History was taken from patients, blood samples for estimation of liver enzymes, bilirubin, fastig blood sugar, albumin, alkaline phosphatase,heamoglobin level, androstenedione level, prolactin level, testosterone level and DHAEA-S level.
There is no statistical significant difference between control and hepatic groups in the biochemical parameters and heamoglobin level.
There were no statistical significant differences in the levels of androstenedione, testosterone and DHEA-S between hepatic patients and controls.
Our study showed that the mean of androstenedione of hepatic patients was signtificantly higher than the controls.
There was a statistical difference between patients and controls in the mean of DHEA-S . The mean of hepatic patients was statistically lower than the mean of control group.
In the case of testosterone , there was a sighificant statistical difference between the mean of hepatic patients and controls as the mean of hepatic patients is higher than the controls.
The mean of prolactin was significantly higher in patients in comparison to controls.
In conclusion , hormonal profile could be estimated for follow up for HCV male patients in order to screen for the patients in order to screen for patient’s fertility and sexual functions.