الفهرس 
AcknowledgementsOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide and currently represents the leading cause of death amongst cirrhotic patients. Many causative factors of HCC have been incriminated, including viral infection, alcohol, aflatoxin, cirrhosis, and other metabolic diseases. However, the contributing factors for the development of HCC in 25% of cases remain unknown.
Tumor act as the enhancement of latent antitumor immune response by chemotherapy, which it may release tumor antigens that could be up taken by antigen presenting cells, processed, and presented to naive T cells. Cisplatin is considered one of the most important chemical treatments for cancer.
Chicory extract (inulin) is a naturally occurring polysaccharide consists of a mixture of oligomers and polymers containing 2 to 60 β, 2-1 linked D-fructose molecules.
The aim of the present study is to elucidate the role of naturoceutical agent including chicory extract (Inulin) as a chemo-sensitizer to cisplatin treatment of thioacetamide induced experimental hepatocellular carcinoma rat’s model. This was achieved in terms of several biomarkers associated with hepatocellular carcinoma particularly those related to oxidative stress, apoptosis and inflammation process.
In conclusion, the present data indicated the efficacy of chicory extract (inulin) supplementation as an anti-hepatocellular carcinoma in addition to its ability as a chemosensitizer for cisplatin treatment. This is mediated by intracellular pathways, involving improvement the alterations in liver functions as well as other aspects of HCC, the suppression of oxidative stress and modulation of antioxidant defense mechanism. Thus, supplementation with chicory extract may help in safe application of cancer technology in medicine as well as in many other aspects of nowadays life. Fractionation guided evaluation could help in the development of ideal anticancer in the near future.