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Abstract This clinical study was performed on 80 individual subdivided into 4 groups: Group I: (Sitagliptin group): included 20 recently diagnosed type 2 diabetic patients receiving Sitagliptin 100 mg once daily before breakfast. Group II: (Vildagliptin group): included 20 recently diagnosed type 2 diabetic patients receiving Vildagliptin 50 mg twice daily before meals. Group III: (Metformin group): included 20 recently diagnosed type 2 diabetic patients receiving metformin with doses ranging from 1000-2000 mg daily after meals. And, Group IV: (control group): included 20 apparently healthy volunteers of matched age and sex. All the included patients and controls were subjected to the followings: 1. Careful history taking 2. Physical and clinical examination 3. Laboratory examination, including: 4. Fasting blood glucose level and 2-hr postprandial glucose level. 5. Glycosylated Hb level (HbA1c). 6. Complete blood count 7. Liver function tests: (ALT, AST, bilirubin and serum albumin) 8. Renal function tests: (serum urea and creatinine) 9. Lipid profile: (total cholesterol, serum triglycerides, LDL , and HDL) 10. Serum insulin level. |