الفهرس 
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Abstract
Background: Central venous pressure (CVP) is the pressure within the superior vena cava and its monitoring helps to assess cardiac functions. Application of positive pressure ventilation may be a factor that affects CVP values. Aim: The aim of this study is to investigate the relationship between CVP values and positive pressure mechanical ventilation among cardiac versus non-cardiac patients in the intensive care units at Cairo University Hospitals. Design: Descriptive Correlational comparative research design was utilized in the current study. Sample: 82 adult mechanically ventilated patients on positive airway pressure ventilation with steady circulatory state. Divided into two equal groups; Cardiac and Non-cardiac groups. Setting: This study was conducted at he Critical Care Department, which is affiliated to Cairo University Hospitals in Egypt. Tools: demographic & medical data sheet, and Patient’s assessment sheet. Results: By evaluating the CVP values within each group separately, it was found that in both groups, the Non-cardiac and the cardiac group, there was a statistically significant change of CVP values ON and OFF ventilatory support. There was statistically significant difference in CVP OFF ventilatory support, ∆ CVP and the % ∆ of CVP when applying different levels of total inspiratory pressure and pressure support. Conclusion: Based on the current study results it can be concluded that, central venous pressure values increases with application of positive pressure ventilation. The lower the total inspiratory pressure, the higher the change of CVP values especially in non-cardiac patients. Recommendations: Regardless the level of positive inspiratory pressure, nurses should exclude the effect of mechanical ventilator when measuring the CVP for the non-cardiac and cardiac patients. This could be done by transient disconnection of the mechanical ventilation during CVP assessment unless it is contraindicated.