الفهرس 
chapter 1Only 14 pages are availabe for public view
 |  | from | 203 |  |  |
| | | from | 203 | | |
Abstract
Thyroid hormones have maked effects on the groth development and metabolic function of virtually all organs and tissues. It is well kowon that changes in the thyroid state are associated with marked alterations in spleen.
Folic acid is water- soluble vitamins which are essential in our life .NUMEROUS CLINICAL TRIALS using folic acid for prevention of cardiovascular disease stroke cognitive decline and neural tube defects have been completed or are underway Folic acid status is also affected by hypothyroidism in healtyy individuals folic acid is converted to L-methyl folate which is the biologically active form of the vitamin.
Hyperthyroidism is a common metabolic disorder with prominent cardiovascular mainifestations It causes a typer dynamic circulatory state because of a marked reduction in peripheral vascular resistance and an increased total blood volume and heart rate.
This work aimed to declare the effect of high thyroid hormone status on oxidative stress parameters and total antioxidant parameters the impact of these biomarkers on the spleen and blood of hyperthyriod rats the present study also aimed to elucidate the role of folic supplementation in building up the antioxidant status as a concurrent treatment in hyperthyroidism and as a post- norvigicus ) weighing 120-10g and of 8-9 week age The rats were equally divided in to six groups (10 rats each)
G1:Negative control group that included animals that received on treatment .
G2:Folic acid group in which animals received folic acid daily for six weeks from 2nd week 8th week .
G3:hyperthyroid rats group in which rats received L- Thyroxine solium adiministration
G4:C0-treated hyperthyroid with folic acid
G5: Post treated hyperthyroid rats with folic acid group.
G6:self recovered hyperthyroid group.
Biochemical investigations:
Serum T3,T4 and TSH concentration in the control and xperimental groups Serum T3,T4 levels were a significant increase in hyperthyriod rats when compared with the control group. Serum T3and T4 levels were a significant decrease in treated hyperthyroid with folic acid when compared with hyperthyroid group. On the other hand serum T3 and T4 levels were a significant increase in crease in co-treated hyperthyroid rats group when compared with post treated hyperthyroid one