الفهرس 
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Abstract
The present study deals with design, synthesis and biological evaluation of new pyrrol-2(3H)-one, pyridazin-3(2H)-one derivatives and pyridazin-3(2H)-one/oxime hybrids. The thesis includes four main parts; Introduction, Scope of Investigation, Results and Discussion and Experimental part. The first part Introduction presented an overview about pyridazinone and pyrrolone synthesis and their biological activities including phosphodiesterase III inhibition and anticancer activities. Additionally, this part includes the biosynthesis and physiological activities of NO. Also, this part involves a literature survey about some of NO donors and their ability to release NO, focusing on oximes and their biological activities. Scope of investigation, results and experimental parts showed that synthesized compounds recorded good results as antiproliferative, antitubulin and phosphpodiesterase III inhibitors.