الفهرس 
Introduction
Epidemiology and prevalence of hyponatremia in liver cirrhosisOnly 14 pages are availabe for public view
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Abstract
Hyponatremia is a common problem in patients with advanced cirrhosis. The pathogenesis of hyponatremia in these patients is directly related to the hemodynamic changes and secondary neurohumoral adaptations that occur, resulting in an impaired ability to excrete ingested water. The severity of the hyponatremia is related to the severity of the cirrhosis.
We conduct this prospective study in Assuit University Hospital during period (from April2014 to Feburary 2015).
Main aim was to study serum natremia and its effects on health related quality of life in patients with liver cirrhosis.
In this prospective study, conducted in 80 patients hospitalized with liver cirrhosis, the prevalence of hyponatremia at a serum sodium concentration ≤135 mmol/Lwas (79%), and normal serum level >135was (21%).
The characters of the studied groups according to the sex showing (group A) included 63 patients 57% were males and 42.9% were females, while (group B) 76.5% were males and 23.5% were females (23.5%) and their ages range between 18-79 years.
In our study hyponatremia was found to be an independent predictor of poor HRQOL in all SF-36 domains (Pain, mental health, role emotional, social functioning, role physical) as a generic questionnaire.
We found that all patients with hyponatremia had significant difference in most SF-36 domains when comparing patients without hyponatremia predominantly through physical impairement and social functioning.
In our study we found that hyponatremia had poor quality of life with all domains of CLDQ (abdominal symptoms, systemic symptoms, activity, worry, emotional functioning) when comparing with patients without hyponatremia.
In our study we found a significant correlation, both in univariate and multivariate analysis between serum natremia and HRQOL. Literature data on the influence of natremia on HRQoL are limited.
I n our study we found that reduced serum sodium concentration, but > 130 mmoL/L is an important negative predictor of quality of life in patients with liver cirrhosis.
In our study we found that serum natremia along with indices of the severity of liver disease exerts a significant effect on patients’HRQoL.