الفهرس 
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Abstract
Spirulina is gaining more attention from medical scientists as a nutritional and therapeutic strategy, thus this work has been carried out to investigate the effect of oral supplementation of spirulina in alleviating the hepatotoxic effect of diclofenac sodium on broiler chicks through evaluation effect of spirulina platensis on hematological, biochemical, antioxidant parameters as well as immunological and histopathological studies. Diclofenac-treated animals induced high mortality rate, normocytic normochromic anemia, significant increase in serum biochemical parameters related to liver injury (AST and ALP), total cholesterol, uric acid and oxidative damage biomarkers also increased while antioxidant biomarkers, total proteins and albumin showed significant decrease. Oral supplementation of spirulina counteracts the deteriorating effects of diclofenac sodium especially in hematology, biochemical parameters and succeeded to improve the endogenous antioxidant enzymes’ activity. Consequently, it could be concluded that spirulina supplementation able to alleviating the toxic effect of diclofenac sodium by their potent antioxidant and free radical-scavenging activities.