الفهرس 
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Abstract
The aim of the present work was quantitative determination of ciprofloxacin and doxycycline residues in different rabbit tissues (liver, muscle, kidney, spleen, blood, heart and lung) following multiple oral doses of these drugs. Reversed phase-high performance liquid chromatography (RP-HPLC) and solid phase extraction (SPE) were used for determining these antibiotic residues concentrations in serum and tissue samples.
The tissue residues of ciprofloxacin and doxycycline:
Experimental design:
•Fifty healthy rabbits were used in this experiment.
•Twenty five rabbits were used in each drug analysis experiment.
•Four rabbits are control in each in each experiment. These rabbits were used for preparation of (blank sample and spiked samples for method validation).
•Twenty one rabbits were given the drug directly into the stomach through stomach tube orally at a dose of 5 and 10 mg/kg b.wt once daily for 5 consecutive days for ciprofloxacin and doxycycline, respectively.
•Three rabbits were slaughtered at each experiment at 1st, 3rd, 5th, 7th, 9th, 15th and 21st day following the last oral dose.
•Samples from blood, heart, lung, liver, spleen, muscle and kidney were taken from slaughtered rabbits for each drug assay.