الفهرس 
3.1. Lead (Pb)Only 14 pages are availabe for public view
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Abstract
Human activity he last few decades has led to global contamination by organic and inorganic compounds. Nowadays, heavy metal contamination is considered to be among the most serious environmental problems. So, the aim of the present study was to evaluate some poterntial therapeutic effect of some vegetales and fruits (coriander, Malva sylvestris and Ficus sycomorus) to get rid of toxic heavy meatals(Lead and Mercury) in albino rats. Experimental design: Biological experimental was done at the Central Laboratory of Research Institute of Ophthalmology, Medical Analysis Department, Giza, Egypt. Rats (n = 54 rats) were housed individually in wire cages in a room maintained at 25 + 2oC and kept under normal healthy conditions. All rats(54 rats) were fed on basal diet for one – week before starting the experiment for to learn non-lethal dose. After this week, they were divided in to nine main groups: Group (1): Rats were fed on basal diet as negative control group. Group (2): Rats were fed on basal diet with 0.2% lead as appositive control Group (3): Rats were fed on diet on diet with 0.02% mercury as appositive control. Group (4): Rats were fed on diet with 0.2% lead and 15% Ficus sycomorus. Group (5): Rats were fed on diet with 0.02% mercury and 15% Ficus sycomorus. Group (6): Rats were fed on diet with 0.2% lead and15% Malva sylvestris. Group (7): Rats were fed on diet with 0.02% mercury and15% Malva sylvestris. Group (8): Rats were fed on diet with 0.2% lead and 15%coriander sativum. Group (9): Rats were fed on diet with 0.02% mercury and 15% coriander sativum. At the end of experimental the following was done: Rats were weighted, and then body weight gain and feed efficiency ratio were calculated.Blood samples were collected after 12 hours fasting then centrifuged to separate the serum which used for the following analysis: Glucose levels. Lipid profile. Liver functions (GPT,GOTand ALP)Kidney functions (creatinine,urea and ALb. Complete blood picture. Absorption( P, Mg and Ca ) and levels of serum( P, Mg and Ca ) . The organs: Liver and brain for histopathological testing. The data were statistically analyzed using cost at computer program by one way ANOVA. The results are presented as Mean+ SD differences between treatments of P ≤ 0.05 were considered significant The obtained results showed that: Biological results: 1. The effect on BWG%,FI and FER These results denote that a significant decrease in FI of rats fed on basal diet with lead and mercury when compared with negative control group. All rats poisoned by lead and mercury and fed on Ficus, Malva; Coriander had a significant increase in FI as compared with positive control groups. Rats were given lead and mercury with coriander showed the highest values in FI compared to Ficus and Malva Concerning body weight gain percentage (BWG%), it is clear that the body weight percentage significantly increased when fed rats the toxic material with tested plants when compared with positive control groups while significantly decreased as compared with negative control . There is no significant change among the groups fed on Coriander with lead, mercury and Malva with mercury. Also, there are no significant differences between the group fed on Ficus with mercury and Malva with lead. The lowest improvement recorded in Ficus with lead. Regarding feed efficiency ratio (FER), it was found that in rats fed with lead and mercury without treatment, FER was the lowest value when compared the negative groups and the groups fed on toxic materials and the tested plants. FER of rats fed on lead with Malva, Coriander and mercury with tested plants showed non-a significant changes. The lowest value recorded in case of Ficus with lead when compared with negative control group and the other tested plants with toxic materials Potential health problems associated with a high intake of lead and mercury have been linked to decreased energy intakes and the weight loss epidemic as indicated. The effect on organs weight: It is obvious that the relative liver weight in groups 4, 5 and 8 showed no a significant as compared to control positive group (G3). At the same time, relative liver weight in groups 6,7and9 recorded non-a significant differences between these groups and significant differences as compared to negative control. By regards to relative kidney weight, it was a significantly reduced in the other groups as compared to control negative group while, there is no significant differences between groups 4, 6 and 9 as compared to control positive group (G3)The effect on lipid profile: The result indicated the lipid profile of infected rats for 4 weeks, a significant, morel increases at the levels of TC, TG, LDL, in addition to the significant decrease at the level of HDLc. On the other side, the groups affected by lead and mercury with feeding on some vegetables and fruits, showed noticed improvement