الفهرس 
Definition of hydrazonesOnly 14 pages are availabe for public view
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Abstract
This chapter contains the chemical and instruments used in
Practical part of thesis as follow: 1) Preparation of the hydrazone ligand and its metal complexes. 2) characterization of the ligand and its complexes using: Physical techniques such as molar conductance and magnetic susceptibility. Elemental analyses (C, H, N, Cl and M). Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra and ESR measurements. Thermal techniques as DTA. and TGA. 3) Measurement of biological activity. This chapter includes characterization of the ligand and its complexes. The ligand 1, 2-bis (phenylamino) vinyl)hydrazono)methyl)phenol was prepared as follow: 1- Condensation of aniline with of ethylchloroacetate (2:1) for one hour to obtain 1, 2-bis (phenylamino)ethenol. 2- Condensation of 1,2-bis(phenylamino)ethanol with of hydrazinehydrate for two hours to obtain 1-hydrazinyl-N1,N2-diphenylethene-1,2-diamine. 3- Reaction of 1-hydrazinyl-N1,N2-diphenylethene-1,2-diamine with of salicyaldehyde with stirring for thirty minutes to obtain 1,2-bis(phenylamino) vinyl)hydrazono)methyl)phenol. The reaction of the ligand with Cu(II), Ni(II), Mn(II), Fe(III), Co(II), Zn(II), Cd(II), Pb(II), Sr(II), and Tl(I) complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectroscopy, (magnetic moments, conductance) measurements, (elemental and thermal) analyses. The IR spectral data show that, the Schiff base behaves as a neutral bidentate or monobasic bidentate ligand bonded to the metal ions through the azomethine nitrogen atom and hydroxyl oxygen atom in protonated or deprotonated form adopting either octahedral or tetragonally distorted octahedral geometries. Molar conductance in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) or d(Z2) ground state with a significant covalent bond character. However, Co(II) complexes (6-7), Fe(II) complex (8) and Mn(II) complexes (9-10), show isotropic type indicating an octahedral geometry. Cytotoxic evolution of the ligand and its complexes have been carried out. Complexes show enhanced activity in comparison to the parent ligand. Metal complexes (2), (3), (4), (5), (9), (10), (14) and (15) were evaluated against HEPG-2 cell line and MCF-7 cell line showed better chemotherapeutic effect against HEPG- 2 cell line than the standard drug used. Also, the Cu(II) complex (3) shows the highest potency of inhibition at 50 μg/ml against HEPG-2 and MCF-7 cell lines, compared with the standard drug. Also, Complexes of Cu(II) (2), (4) and (5) and Mn(II) complex (9) with Schiff bases show antibacterial and antifungal activities.