الفهرس 
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Abstract
Colloidal solution of Gold nanoparticles posses unique optical and photothermal properties due to what is called surface Plasmon resonance The surface Plasmon is the oscillation of metallic surface electrons due to interaction with the incident light. This leads to very strong absorption of the visible light which efficiently converted into heat. Gold nanoparticles could be directed selectively into the malignant cells, using antibody-antigen interaction scheme. For this reason, gold nanoparticles have been proposed recently as a new category of photothermal cancer therapy. Biosafety assessment experiment should be proceeded in order to evaluate the toxicity and determine the safety dose of nanomaterials. The aim of this study is to evaluate in vivo potential toxicity of gold nanoparticles and magnetite-Au core shell nanocomposite in mammals. The gold particles are prepared chemically by citrate method and the particle size as well as the particle shape has been determined using transmission electron microscopy (TEM). The optical properties shows that the prepared particles have strong absorption at 523 nm. The magnetite nanoparticles have been prepared using co-precipitation method and these particles used as a seed toform further shell of gold upon them. The TEM images indicate that the core is about 15 nm, and the average size of the total particles is 18 nm. Thismeans that the gold shell is about 3.0 nm. The particles after preparation and purification have been dispersed in saline solution.