الفهرس 
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Abstract
More than 1 million percutaneous coronary intervention procedures performed annually worldwide to relieve the symptoms of coronary artery disease. Restenosis of the treated segment occurs in 32% to 57% of patients undergoing balloon angioplasty within 6 months of the procedure (Simon et al., 2001).Despite consistent and compelling clinical trial evidence that intracoronary radiation with β or γ sources is capable of effectively treating in-stent restenosis, significant adverse effects (excessive vascular damage producing pseudoaneurysms, total vessel occlusion, or atherosclerosis; delayed stent thrombosis; and possible risk of neoplasm in surrounding tissues) may limit its widespread application. Several studies had showen that PDT inhibits SMCs growth and decreases the development of experimentally induced intimal hyperplasia. PDT can deplete the arterial media of vascular smooth muscle cells and reduce neointima formation following arterial injury.