الفهرس 
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Abstract
Introduction:- In this study we estimate the role of fish oil in preserving the skin and hair against dramatic changes of diabetes and or hypercholesterolemia in male Wistar albino rats. Forty male Wistar albino rats weighing approximately 100 g body weight were used in the present study. They were arranged into 8 groups; control, fish oil-supplementation (100 mg/ kg every other day), diabetes (streptozotocin 40 mg/kg single dose in citrate buffer pH 4.6), hypercholesterolemia (3% cholesterol), diabetes & hypercholesterolemia, diabetes and or hypercholesterolemia & fish oil.Methods: after 12 weeks of treatment, the animals were sacrificed by lightly anesthetize with ether and decapitated. Their skin and hair were collected from their dorsal abdomen. They were subjected for scanning and transmission electron microscopy, immunohistochemistry, flow cytometry investigations and assessments of lipid, fatty acids, keratin, elastin, collagen 3 and collagen 4 of the skin and also skin contents of interleukin 2 & 3, tumor necrosis factor and vascular endothelial growth factor and protein carbonylation and glycation end product. And also it has been identified the amino acids, minerals, and keratin and protein carbonylation and glycation end product of the hair.Results: The finding revealed apparent deformation in epidermal cell layers and dermis, alterations of skin lipids, fatty acids and increase of biomarkers of cell damage. And also reduction of hair shaft thickness, alterations of some essential and non-essential amino acids of hair. In addition, the skin and hair showed increase of protein carbonylation and glycation end product as well as keratin formation. Fish oil-treatment ameliorates the morphological structure and skin contents as well as reduces the formation of glycation end products and restores the loss of keratin.Conclusion: The author finally concluded that that fish oil supplementation improve the histopathological picture and skin and hair structure and function of rats subjected to diabetes and or hyper cholesterolemia which may be due to scavenging of free radicals or support skin with fatty acids required for repairing the elementary structures of skin and hair follicles.