الفهرس 
Properties of guanidineOnly 14 pages are availabe for public view
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Abstract
The Ph. D. thesis includes three main chapters
Aim of the work:- The work aimed to prepare and characterize a new guanidinium ligand and its metal complexes aiming to study their effects on both microbial and tumour diseases.
1- Introduction
This chapter includes introduction to guanidine and its types and nomenculture and an overview of the previous researches on complexes of guanidine ligands and their applications.II-Experimental
This chapter contains the chemical reagents and equepiments used for measurement of different parameters all over the work as follow:
1) Preparation of the guanidine ligands and its metal complexes.
2) characterization of the ligands and their complexes using different methods:
Physical techniques such as molar conductances and magnetic
susceptibility
•Elemental analyses (C, H, N, CI and M).
•Spectral techniques as IR, (UV- Vis.), IHNMR, mass spectra and ESR measurements.
•Thermal techniques as DTA. and TGA
3) Measurement of biological activity for the prepared complexes.
111- Results and discussion
This chapter includes characterization of the ligands and their complexes. The first ligand was prepared as follow:
1- Condensation of thiourea with hydrazine hydrate (1: 1) for three hours to obtain the hydrazide.
2- Condensation of methylacetoacetate with the hydrazide (1: 1) for three hours to give the ligand.
(2E,2’E)-2,2’-(hydrazine-1 ,2-diylidene )bis( 6-methyl-2,3¬dihydropyrimidin-4( 5H)-one) ligand reacts with Mn(ll) , Co(ll), Ni(ll) , Cu(ll), Zn(ll) , Cd(ll), Mg(ll), Hg(ll), Ag(I), TI(Ill), Fe(Ill), Cr(llI), ZrO(ll) and D02(ll) ions to form octahedral or square plannar complexes. Their structures are characterized by elemental analyses, IR, Dv- Vis spectra, magnetic moments, molar conductances, IH - NMR and mass spectra (ligand and its Zn(ll) complex), thermal analysis (TGA) and ESR measurements. The molar conductances of the complexes in DMF are commensurate with their non- ionic character. The ESR spectra of solid Cu(ll) complexes show axial or isotropic type symmetry (dx2 - y2) ground state with covalent bond character. However, Co(ll), Mn(ll), Fe(llI) and Cr(Ill) complexes show isotropic type. The invitro anticancer activity breast tumor cells and antifungal screening Aspergillus Niger fungi of some complexes have been investigated.
The second ligand was prepared as following :-
1- Condensation of thiourea with hydrazine hydrate (1: 1) for three hours to obtain the hydrazide.
2- Condensation of salicylaldehyde in excess with the hydrazide (1:4) for three hours to give the ligand.
A new series of symmetric and asymmetric binuclear Mn(ll) , Co(ll), Ni(ll), Cu(ll) , Zn(ll), Cd(ll), Hg(ll), TI(Ill) and D02(ll) ion complexes of have been synthesized and characterized by elemental analyses, IR, DV - Vis, magnetic moments, conductances, mass spectra, IH_ NMR, thermal analyses (DTA and TGA) and ESR measurements.
The IR spectral data show that, the ligand behaves neutral, tetradentate or tetrabasic octadentate. Molar conductances in DMF solution indicate that, the complexes are non- electrolyte. The ESR spectra of the solid complexes show axial or isotropic type with covalent bond character. Antimicrobial and antitumor teste of the ligand and some complexes are also carried out and it has been observed that the complexes are more potent.