الفهرس 
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Abstract
Our results aimed to representthe application of gold nanoparticles (AuNps) as drug carrier in cancer therapy and diagnosis.Gold nanoparticles have unique optical and chemical properties that make them ideally suitedfor a number of applications in bionanotechnology, including optical probes, targeted drug delivery, and programmed materials synthesis. The recurring theme is the versatility of goldnanoparticles and how this versatility can be exploited to adapt gold nanoparticles to fit into different chemical environments—from aqueous suspensions to the hostile conditions of a cell culture.Cancer is the leading cause of death worldwide, it accounted for 7.9 million deaths in 2007. In the Eastern Mediterranean region, for example; cancer incidence is expected to increase by 100% to 180% in the next 15 years.Advances in nanotechnology and its applications in biomedical science and engineering over the past two decades have enabled numerous innovative and more effective cancer diagnoses and treatment modalities.Cancer nanotechnology is a new field of interdisciplinary research cutting across biology, chemistry, engineering and medicine aiming to lead major advances in cancer detection diagnosis and treatment. Creating nanomaterials such as nanoparticles, nanorods, nanowires, nanotubes and thin films are the key components for successful development of nanotechnology.Studying metallic nanoparticles attracts great interest because of theirunusual chemical and physical properties which make them suitable for manytechnological applications such as catalysis, electronics, optics, andbiotechnology. The rich surface chemistry of AuNPs allows surface modification reactions with wide varieties of chemical and biochemical vectors to tailor to the needs of biomedical applications like imaging and therapy of cancer. AuNPs provide attractive vehicles for delivery of drugs, genetic materials, proteins, and small molecules. It feature low core toxicity coupled with the ability to parametrically control particle size and surface properties.The use of heat has become one of the major methods for tumor therapy later heating sources ranging from radiofrequency to microwaves as well as ultrasound waves were introduced to induce moderate heating in a specific target region, which is termed as hyperthermia.Ionizing radiation induces multiple biological effects through direct interaction with DNA or production of activated free radical species from water The platinum drugs represent a unique and important class of antitumor agents. Cisplatin (CIS) has a broad spectrum against various types of human tumors and especially useful in the treatment of epithelial malignancies, oesophagus and lung.In this work gold nanospheres proved to be highly effective as drug carrier.AuNps have been prepared by chemical method; characterization and photostability of these particles has been studied Moreover the binding of anticancer drug CIS with AuNps has been verified using various techniques (UV- Visible absorption spectroscopy – TEM – FTIR spectroscopy).