الفهرس 
Vitiligo
Contraindications of ER:YAG Laser tissue ablationOnly 14 pages are availabe for public view
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Abstract
Vitiligo is an acquired leukoderma that results from the loss of epidermal melanocytes, and is characterized by macules and patches of depigmented skin. The pathogenesis of vitiligo is not yet fully understood, but the autoimmune hypothesis is the most commonly accepted one. Many treatment modalities have been described. Although many therapeutic options exist and new modalities are still emerging, treatment challenges persist, as not all patients respond to available therapies. NB-UVB Phototherapy is very important modality in vitiligo treatment but require more than one year for its completion. Topical 5-flurouracil could improve the proliferation and migration of melanocytes. Dermabrasion (either mechanical or laser assisted) results in stimulation of the amelanotic (inactive) melanocytes present at the outer root sheath of the lower portion of the hair follicle which proliferate and migrate upwards and start actively synthesizing melanin at the infundibulum and from there they migrate further until they reach the surface of the skin.