الفهرس 
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Abstract
Management of furcation involvement is one of the most challenging tasks in periodontal therapy. Because of the limitation of current bone grafting methods, alternative methods for repairing bone defects were deemed necessary.
Drynaria rhizome [Drynaria fortunei (Df); Gu-Sui-Bu in Chinese] extract is a common type of traditional Chinese herb in the area of orthopedics with proved stimulative effects on the proliferation of osteoblasts and promotion of osteogenic differentiation of bone mesenchymal stem cells.
The aim of the present study was to evaluate, histologically, and analytically the possible role of Df in the management of induced class II furcation defects in dogs using guided tissue regeneration (GTR) with an osteoconductive bone graft material (ß-TCP).
Third and fourth mandibular premolars of 4 healthy mongrel dogs were used. Sixteen class II furcation defects were surgically created and managed as follows: 8 defects [experimental group (I)] were managed with GTR and Df granules and 8 defects [control group (II)] were managed with GTR only. Dogs were sacrificed at 4 and 8 weeks intervals and the premolars have been histologically processed for evaluation of the regenerative process outcome. Image J software was used to measure osteoblastic count (OC), cementum layer thickness (CLT) and percentage of collagen in bone matrix (CBM). Student t test was carried out to determine differences between groups.
After 4 weeks of applying (Df) into the furcation defects, descriptive histological results indicated the formation of new mature lamellar bone compared to immature woven bone in control group.
Moreover, quantitative analysis using Image J software showed highly statistically significant increase in (OC), (CLT) in group (I) (P<0.0001). After 4 weeks, there was highly statistically significant decrease in (CBM) in group (I). After 8 weeks there was a decrease in (CBM) in group (I), but it was not statistically significant.
Within the limitations of the present work; it could be concluded that Df is biocompatible and a bone inducing material that can be easily applied in periodontal regenerative procedures.