الفهرس 
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Abstract
Objectives: This study was designed to evaluate, clinically and radiographically, the effect of new three different monoblock obturation systems (RealSeal SE, ActiV GP, and EndoREZ) on the healing of perapical lesions. Also to evaluate the sealing ability, adaptation, and antibacterial effect of these obturating systems. Materials and Methods: A total of forty healthy individuals with non-vital pulp and an apical radiolucency were selected for this study. They were randomly divided into four groups, (n=10) according to obturation system used; AH Plus, RealSeal SE, ActiV GP, and EndoREZ. The canals were prepared and obturated according to manufacture recommendations. The patients were recalled for clinical and radiographic evaluation at 3,6,12, and 18 months intervals. For microleakage test, canals of sixty single rooted human teeth were prepared and obturated by the four tested materials and microleakage was determined using dye extraction method. Representive samples from each group were used to evaluate the adaptation of the obturation materials to canal walls using SEM. Agar-well diffusion method (AWDM) with cultures of E.faecalis, S. mutans, E. coli and C. albican were used to test the antimicrobial effect of the tested materials.Results: The results of clinical and radiographic evaluation using Qui-square test showed no significant difference between different groups. Dye extraction test using ANOVA test revealed significant difference between EndoREZ and both AH Plus and RealSeal SE, with no significant difference with ActiV GP. Scanning Electron Microscope study presented no gap formation with EndoREZ and ActiV GP groups, while gap formation was observed with AH Plus and RealSeal SE groups. ANOVA test for antimicrobial effect revealed that ActiV GP had the most significant effect against all micro-organisms used in this study, and EndoREZ exhibited the lowest antimicrobial effect.Conclusions: Monoblock obtutration systems had a comparable healing potential to that of conventional sealers (GP/AH Plus), inspite of their proper sealing ability and better adaptation to canal walls. ActiV GP has the most antibacterial effect among monoblock obturation systems.