الفهرس 
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Abstract
Oral squamous cell carcinoma (OSCC) represents the most frequent of all oral neoplasms. It is estimated that more than 90% of all oral neoplasms are OSCC cancers. Ki-67 is a cancer antigen that is found in growing, dividing cells but is absent in the resting phase of cell growth making it a good tumor proliferation marker. Suprabasal expression of Ki-67 provides objective criteria for determining the severity of dysplasia and histological grading of OSCC and can be used as an objective marker to evaluate the grading of epithelial dysplasia and OSCC. The present study investigated the correlation between Ki-67 nuclear protein with clinical stages of OSCC cases, different microscopical cell differentiation and lymph node metastasis. The expression of Ki-67 in OSCC was determined immunohistochemically in 50 patients. The results of the present study showed high statistically significant correlation between different histopathological features of SCC as well as its clinical stages, lymph node involvement and Ki-67 expression. These findings suggest that Ki-67 is a good proliferation marker in indicating aggressiveness of the tumor.