الفهرس 
Introduction and Aim of WorkOnly 14 pages are availabe for public view
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Abstract
Enzymes are biocatalysts produced by living tissues characterized by high specificity for particular type of reaction. The products of an enzyme reaction in one tissue component may have significant effects on a separate enzyme process in another component of the given tissue or even in an entirely different tissue . Some detailed knowledge of enzyme distribution within cells and of the chemistry and function of enzymes is therefore essential for a detailed understanding of disease mechanisms and therapies. Enzyme activity may be high in some diseases and low or lacking in others . Enzyme assay are also of growing importance in the detection of heterozygous carriers of hereditary diseases (Baron et al., 1975) .
Isoenzymes are multiple forms of an enzyme family having the same catalytic activity. Isoenzymes differ in many of their physico -chemical characters . They can be separated by different methods . Each isoenzyme of a family has different affinity for substrates . Living cells release enzymes and isoenzymes, increases in the level of release are associated with a variety of pathological abnormalities (Lanter, 1968) .
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So quantitative assay of selected enzyme and isoenzyme activities in blood and other body fluids can assist in the diagnosis and prognosis of diseases (Baron et al ., 1975 ) .
Beta glucuronidase is a lysosomal hydrolase ( De Groen et al ., 1989) . The enzyme was first described by Rohmann in 1908 and first named by Masamune in 1934 .
The molecular weight of the enzyme is in the range of 280,000 D-300,000 D (Nakamura et al., 1990) .
There is an ELISA developed for the detection of the enzyme in serum ( Ohta et al., 1992 ) .
Inherited deficiency of beta glucuronidase activity have been described as autosomal recessive trait in man ( Sly et al., 1973 ) .
The increased level of the enzyme in urine of patients with nephrotic syndrome, made the enzyme useful in the diagnosis of nephrotic syndrome and in the evaluation of it’s course ( Guszoznski et al., 1991 ) Abnormally high levels of beta glucuronidase was encountered in the fascioliasis cases pointing to liver damage caused by the fluke ( Ebied et aI.,1993 ) .
The aim of this work is to throw a flash of light on functions, deficiency, increased level of the enzyme, it’s relation to various diseases and it’s assay methods .