الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 90 |  |  |
| | | from | 90 | | |
Abstract
This study was planned to detect the diagnostic use of serum ferritin levels in differentiation between infectious and noninfectious causes of fever of unknown origin in Menouf Fever Hospital.
The present study was conducted on 40 patients diagnosed with fever of unknown origin and 20 of healthy volunteers as a control.
They were categorized into 3 main groups:
group I Patients with Patients withPatients with Patients withPatients withPatients with Patients withPatients withPatients with FUO due to infectious causes.
group II Patients with Patients withPatients with Patients withPatients withPatients with Patients withPatients withPatients with FUO due to non infectious causes.
group III Twenty healthy volunteers of matched age and gender.
Patients of this study were selected from patients attending Menouf Fever Hospital in period from July 2013 to June 2014.
All patients and control groups were subjected to the following:-
1. Full history taking.
2. Complete clinical examinations.
3. Laboratory investigations:
Complete blood picture: (HB%- WBCS - platelets)
Urine analysis.
Stool analysis.
Liver function tests including: (ALT, AST, Serum bilirubin, serum albumin, Prothrombin time, alkaline phosphatase).
Renal function tests including: (Serum urea and creatinine)
Widal agglutination test and Brucella agglutination test
Random blood sugar
Cultures of blood, urine and stool in suspected cases
Immunological tests as RF, ANA and ASOT
Tumour markers as AFP and CA 19 – 9
Summary
80
Estimation of serum ferritin level
4. Radiological examination:
Chest X ray, abdominal ultrasonography, computerized tomography (CT) and magnetic resonant imaging (MRI).
5. Invasive procedures :
E.g. Bone marrow biopsy and cytology, lymph node biopsy and cytology.
The results of the study were tabulated, statistically analyzed and graphically represented.
The present study revealed the following results:
There was no significant difference between the studied groups as regards the age and the gender.
There was highsignificant difference between GI (the infectious disease group) and GII (noninfectious disease group)as regards duration of fever preadmission and duration of hospital stay(P<0.001).
There was no significant difference between GI (the infectious disease group) and GII (noninfectious disease group) as regards their symptoms and signs.
The statistical analysis revealed no significant difference between the studied groups as regards CBC.
The statistical analysis showed high significant difference between group I (the infectious disease group) and control group (P<0.001), group II (noninfectious disease group) and control group (P<0.001) and significant difference between group I and group II (P<0.05) as regards ESR.
The statistical analysis showed high significant difference between group I (the infectious disease group) and control group (P<0.001),
Summary
81
group II(noninfectious disease group) and control group (P<0.001) with no significant difference between group I and group II as regards CRP.
The statistical analysis revealed no significant difference between studied groups as regards both liver function tests and renal function tests.
There was high significant difference between group I (the infectious disease group) and control group (P<0.001), group II(noninfectious disease group) and control group(P<0.001) and significant difference between group I and group II(P<0.05)as regards serum ferritin level.
Serum ferritin level was > 555 μg/L as a cutoff point in non infectious diseases in patients with FUOwith sensitivity (75%) and specificity (85%), PPV (77.8%), accuracy (75%) and NPV (72.7%).