الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Endometrial carcinoma is the most common invasive neoplasm of the female genital tract in the USA. In 2015, it is estimated there have been 54.870 new cases and 10.170 deaths resulting from this neoplasm. These figures represent an estimated 7% of the new cancer cases and 4% of the cancer deaths in women
In Egypt, it constituted 0.62% of the total malignancies in females during the years 2008-2011 ranking the second among invasive cancer of the female genital tract after cancer cervix.
Endometrial hyperplasia represents a non physiological, noninvasive proliferation of the endometrium that results in a morphologic pattern of glands with irregular shapes and varying size. WHO newest classification of endometrial hyperplasia classified it into two main categories: endometrial hyperplasia without atypia and atypical hyperplasia/EIN.
Relationship between atypical hyperplasia and endometrial carcinoma has been confirmed by molecular genetics studies confirming that endometrial carcinoma show the same mutations seen in atypical endometrial hyperplasia, indicating that endometrial carcinoma can be preceded by atypical hyperplasia.
Hepsin is one of the type II transmembrane serine protease (TTPs) family. TTSPs are a relatively new subfamily of S1 class serine proteases in humans comprised of 17 proteolytic enzymes. These enzymes are present in a wide range of tissues and biological fluids, and have well-characterized roles in diverse cellular activities, including blood coagulation, wound healing, digestion and immune response. In addition to their roles in normal tissue development and homeostasis, TTSPs are also involved in several human diseases, including cancer.