الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third most common cause of cancer death. It is multifactorial in etiology and complex in pathogenesis. The major risk factor for the development of HCC is liver cirrhosis. Presence of vascular invasion is a very late stage for tumor management and treatment. So it was important to find new prognostic markers to facilitate early prediction of vascular invasion and metastatic potential of the tumor.
This is a retrospective study included 204 liver specimens that were divided into HCC group and non-malignant group (normal liver tissue, chronic HCV infection, cirrhosis with and without HCC, focal nodular hyperplasia (FNH)& hepatocellular adenoma (HCA)).
In this study, we used tissue micro-array technique that included 88 HCC specimens and 66 specimens of cirrhosis adjacent to HCC in addition to paraffin-embedded blocks of the reminder of cases.
Follow up data concerning survival time and recurrence rate after surgery were available for 31cases of HCC.
The median age of HCC cases was 56 years with predominance of male gender 84.7%. Median level of serum AFP was 315 ng/ml and also 94.9% of cases were positive for hepatitis viral infection. Median tumor size was 5.5 cm. 98% of HCC cases were of classic type and showed different grades of differentiation within the same tumor with 57.2% of cases presented with pathological stage T1 and 21.4% showed microscopic vascular invasion. 83.7% of cases occurred on top of liver cirrhosis.