الفهرس 
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Abstract
Despite improved neonatal care over the past decades, infections remain common and sometimes life-threatening in neonates admitted to the neonatal intensive care unit (NICU).
The diagnosis of neonatal sepsis begins with clinical suspicion. The challenge for the neonatal practitioner is to decide which babies need empirical antibiotic therapy but this causes antibiotic overuse and nosocomial infections because of unnecessary hospitalization.
Unfortunately there is no single diagnostic test, which can reliably diagnose sepsis in the newborn, therefore many diagnostic tests are utilized to diagnose or confirm sepsis.
This study was conducted in order to evaluate the diagnostic value of CRP and Alpha 1- acid glycoprotein (α1AGP) in the early diagnosis of neonatal sepsis.
This study was conducted on 50 neonates presenting with symptoms and signs suggesting neonatal sepsis, admitted to NICU of Minia University Hospital of Obstetric and Pediatrics and Bani- Mazar General Hospital. In addition, 25 healthy neonates as control group.
Weak suckling, weak Moro, lethargy and respiratory distress were the commonest presentation of sepsis in our study followed by GIT manifestations, while sclerema and bleeding tendency were the least presentation of sepsis.
Our study reveals higher significant difference regarding TLC between patients and control groups.
On the other hand, highly significant increase regarding I/T ratio was observed in the patients group when compared with that of the controls.
It shows significant difference regarding HB level and platelet count between patients and control groups.
In our study CRP level was found to be very significant statistically between septic group and control groups.
In this study, at a cutoff point of CRP >6 mg /l. the sensitivity was 100% and the specificity was 100% In our study, serum level of α1-AGP was found to be very significant statistically between septic group and control group. There is significant increase in α 1 AGP in septic neonate.
In the current study, at a cutoff point of AGP >1700 mg /dl, the sensitivity was 86% and the specificity was 100%.
There is no single diagnostic test, which can reliably diagnose sepsis in
the newborn, therefore many diagnostic tests are utilized to diagnose or confirm sepsis.