الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Impairment of spermatogenesis has been confirmed before treatment in patients with various malignancies. Also, testicular germinal epithelial damage resulting in azoospermia is a well-known consequence of certain chemotherapeutic agents. The chance of recovery of spermatogenesis following cytotoxic insult and also the extent and speed of recovery, are related to the agent used and the dose received. Transplantation of mesenchymal stem cells (MSCs) which are able to self-renew to maintain the stem cell population and activate the resident testicular stem cells, producing large numbers of differentiating cells of the spermatogenic line, eventually leading to mature spermatozoa that will transmit the genome to the next generation.
This study was designed to assess the ability of mesenchymal stem cells (MSCs) to restore fertility in induced azoospermic mice following cyclophosphamide administration. Forty male mice were divided randomly into two groups.Group1(10 mice), representing control micedid not receive any thing group 2 (30 mice) which divided into 3 subgroup, group 2A including azoospermic mice by cyclophosphamide untreated, group 2B that including azoospermic mice that undergo transplantation of anti-sca 1(hematopiotic stem cell), group 2C that including azoospermic mice that undergo transplantation MSCs into tail vein (caudal vien ) of mice androgen hormonal profile and histological assessment of testicular tissues were evaluated pre- and post-mesenchymal stem cell transplantation.