الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus (HCV) infection is pandemic worldwide and it is a global medical problem. In the previous studies, genetic (host factor) has a crucial role in natural history of HCV. A genetic factor of immune response is believed to contribute to HCV susceptibility. HLA –DRB1 alleles believe to have an important role in immune response against HCV. The aim of the study is to clarify the contribution of HLA –DRB1 alleles in HCV susceptibility in large sample size family-based association study.
Three hundred twenty four Egyptian families with HCV were recruited in this study from 2012-2014. These familiesinclude324 index positive for RNA-HCV and 186 positive members and 588 negative members for RNA-HCV. All subjects were genotyped for HLA - DRB1 alleles by SSP-PCR and sequence based typing (SBT) methods.
HLA–DRB1*130101 (OR=4.0203, 95% CI =2.6716 to 6.0499, P<0.0001) and DRB1*030101 (OR=2.3274, 95% CI=1.4900 to 3.6356, P=0.0002) were risk alleles for HCV infection. DRB1*040101 (OR=1.8956, 95% CI=1.0505 to 3.4205, P=0.0337) DRB1*070101 (OR=3.4186, CI=1. 6605 to 7.0381, P< 0.0001) and DRB1*110101 (OR= 0.0092, CI=1.1970 to 3.5688, P=0.0092) were associated with protection from HCV infection. The P statistics of HLA–DRB1*130101, DRB1*030101, DRB1*070101, and DRB1*110101 alleles remain significant after Bonferroni correction.
Among the Egyptian families, HLA- DRB1*130101 and DRB1*030101 alleles influence HCV infection, while DRB1*070101and DRB1*110101 act as protective alleles against HCV infection.