الفهرس 
Chronobiology
PharmacokineticsOnly 14 pages are availabe for public view
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Abstract
The chronotherapy of allergic rhinitis involves determination of the best time to take antihistaminic and/ or other types of medication to a patient synchronized with circadian variation in allergic intensity. This is to enhance their desired effects and avoid or minimize unwanted side effects. This can be achieved by accurately timing both the dosing time and the release of the drug from the delivery system in synchrony with rhythm-determined requirements. Accordingly, an oral pulsatile drug delivery systems was designed to achieve a therapeutic drug level enough time before and during the allergic attack for maximal relief of allergic attack and this is the main aim of the present work. Loratadine is a tricyclic antihistamine that exhibits specific and selective peripheral H1 antagonistic activity. Loratidine is a suitable candidate for administration by a pulsatile delivery system. This was due to circadian time-dependent differences in the pharmacokinetics (absorbance and clearance) as well as chronotoxicology of loratidine.