الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The present study was carried out to evaluate the possible adverse effects of doxycycline (5 mg/kg and 10 mg/kg) and ciprofloxacin (150 mg/kg and 300 mg/kg) on some semen characters (sperm count and live dead ratio) and some hormonal profile (LH, FSH, and Testosterone) in adult male albino rats. Moreover histological examination of testes, epididymis, liver and kidney was done, with especial references to their effects on some hematological and biochemical parameters. The result of the present study showed that doxycycline and ciprofloxacin revealed a significant decrease in the sperm count, percent of live sperm, and normal sperm morphology % at 14th days post treatment. Also there were a significant decrease in serum LH, FSH, and total serum testosterone hormone levels when compared with the results of control group. Histopathological examination of liver, kidney, testes and epididymis revealed abnormal changes as a result of treatment with doxycycline and ciprofloxacin. Moreover both drugs induced a significant increase in serum ALT, AST, urea, creatinin, and malondialdehyde levels. It was found that both doses of doxycycline and ciprofloxacin induced a significant decrease in total erythrocytic count and Hb value. Also the drugs induced variable changes in differential leucocytic count. Conclusion It could be concluded that, administration of doxycycline or ciprofloxacin to clinically healthy mature male rats induced some fertility troubles (some alterations in each of semen characters, hormonal profile and histopathology of testes and epididymis).