الفهرس 
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Abstract
This work was carried out at Entomological Laboratory, Zoology Department, Faculty of Science, Mansoura University. The experimental colonies were placed in a private apiary at Shoha village, Mansoura city, Dakahlia province, during the period from april to September, 2014. Eighteen healthy honeybee colonies of Carniolan hybrid (Apis mellifera L) were used for this study. Three wild plants were conducted to this study as follows: Marrubium alysson (Family: Labiatae) which collected from Al-Arish, North Sinai province, Lobularia arabica (Family: Brassicaceae) and Malcolmia pygmaea (Family: Brassicaceae), Narjes mountain, Baltim, Kafr El-Sheikh province .This work aimed to investigate the Efficacy of some plant extracts against American foulbrood disease (AFB) caused by paenibacillus larvae, in honeybee (Apis mellifera) colonies as follow:1-Identification and characterization of Paenibacillus larvae2-Preparing plant extracts.3-Antimicrobial activity of the tested plant extracts to Paenibacillus larvae.4-Effect of plant extracts on artificially infected honeybee colonies with AFB disease.5-Biological activities of treated infected bee colonies with plant extracts.6- Histologigal and ultrastructural studies on larval midgut structure.CONCLUSION1.It could be stated that, the plant extracts were considered safe for adult worker bees and could be used in bee colonies without any harmful for bees.2. In August, the symptoms were reappeared only in colonies treated with tylosin with very low value.3.Colonies of Marrubium alysson-treated group and infected group two revealed the highest total monthly average followed by Malcolmia pygmaea-treated group. While, lowest average was showed in tylosin-treated group.4.The highest monthly average of storing pollen/colony in all groups of colonies was found in June.5.Colonies of Malcolmia pygmaea-treated group followed by Marrubium alysson-treated group scored the highest total average of honey storage; whereas infected group showed the lowest one.6. Using plant extracts are very active in controlling AFB disease in honey bee colonies.7.Plant extracts may increase the biological activities of honey bee colonies infected with AFB disease.