الفهرس 
NeuroinflammationOnly 14 pages are availabe for public view
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Abstract
Key words: Parkinson’s disease, Rotenone, L-dopa, GCSF.Background: Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. Its standard treatment resolves its manifestations but does not stop disease progression. Recently, granulocyte colony-stimulating factor (G-CSF) has been reported to directly stimulate proliferation and differentiation of neural progenitor cells and to stimulate anti-apoptotic processes in neurons in addition to modulating the immune system by down-regulating proinflammatory cytokines. Therefore, we investigated the effect of G-CSF on a mice model of PD. Methods: 60 male albino mice were divided into 6 equal groups; Control, Rotenone induced PD group, vehicle group, Rotenone + L-dopa treated group, Rotenone + GCSF treated group, Rotenone + L-dopa and GCSF treated group then behavioral tests were performed, nigrostriatal level of dopamine, malondialdehyde, reduced glutathione, nitric oxide and tumor necrosis factor-α were determined, in addition to histopathological examination of nigrostriatal tissue and immunohistochemical detection of caspase-3. Results:The current study revealed that combination of G-CSF with L-dopa could be better than each alone as evidenced by normalization of behavioral tests in addition to amelioration of the measured neurochemical parameters as well as apparent improvement of the nigrostriatal histopathological results. Conclusion:The present work suggests that G-CSF could be recommended as a promising disease-modifying therapy when given with L-dopa to get benefit from its antiapoptotic,anti-inflammatory and antioxidant effects.