الفهرس 
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Abstract
The work was planned to study the effect of benzo(a)pyrene on pregnant rats and their fetuses .
In the first experiment the pregnant rats administered B(a)P on three doses 12.5 , 50 and 100 mg/kg at 8th , 12th and from 8th to the 12th day of gestation. Rats in all groups were kept under observation till the 20th day of gestation at which they were sacrificed under ether anesthesia. Fetuses were removed from the uterus and evaluated for mortality rate, fetal development through morphological, visceral and growth retardation. External and skeletal malformations and histological changes of liver were examined. This experiment contains five groups. The first group contains 9 pregnant rats reserved distal water and used as negative control. Other four major groups of pregnant rats each of 27 animals were divided into three subgroups. Benzo[a]pyrene was dissolved in corn oil and orally administered at doses 12.5 , 50 and 100 mg/kg b. wt. for the pregnant rats at 8th , 12th (single dose) and from 8th to 12th day of gestation (repeated dose).