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العنوان
Role of Reticulocyte Hemoglobin Content in the Evaluation of Iron Deficiency State in Hemodialysis Patients /
المؤلف
El-Gamil, Ahmed Mohamed Ibrahim Mohamed.
هيئة الاعداد
باحث / Ahmed Mohamed Ibrahim Mohamed El-Gamil
مشرف / Gamal El-Sayed Ibrahim Mady
مشرف / Osama Mohamed Mahmoud
مشرف / Tamer Wahid El- said
تاريخ النشر
2015.
عدد الصفحات
63 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض الكلى
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة عين شمس - كلية الطب - Internal Medicine and Nephrology
الفهرس
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Abstract

Our study was conducted on 90 randomly selected chronic hemodialysis patients receiving their treatments at El-Hamoul Hemodialysis Unit, El-Hamoul Hospital (Ministry of Health Central Hospital) - Kafr El Sheikh, Egypt.
As the inflammation has a significant effect on iron parameters; we tried to compare between reticulocyte hemoglobin content (CHr) and conventional iron indices as transferring saturation (TSAT) & serum ferritin in the assessment of iron status in hemodialysis patients after the effect of the inflammation, and so the patients were divided into 2 groups according to CRP level:
• Low or normal CRP group (<5 mg/dl): consisting of 31 patients.
• High CRP group (>5 mg/dl): consisting of 59 patients.
All patients were evaluated for Hemoglobin (Hb%) , Mean Corpuscular Volume (MCV), Mean corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Reticulocyte Hemoglobin Content (CHr), serum Ferritin, Transferrin Saturation (TSAT), Total Iron Binding Capacity (TIBC), serum Transferrin, Urea Reduction Ration (URR), and C-reactive protein (CRP).
Statistical analysis was conducted on all data resulted, and our study revealed that there was mean Hb of 8.94±2.02 g/dl and mean chr of 30.21±2.77 pg. There was a weak positive correlation between chr and TSAT, Ferritin (r = .281, P= .007) and (r = .229, P= .030) respectively.
However, there was a strong positive correlation with mature red blood cell hemoglobin indices; MCH and MCHC, rs (90) = .851, p = .000 and rs (90) = .632, p = .000 respectively.
On the other hand, there was a weak negative correlation between chr and CRP, rs (90) = -.369, p = .000
The study also revealed that distributions of the chr for both groups were similar, as assessed by visual inspection. Median chr level was statistically significantly lower in patients with inflammation/infection (median value) than in patients with no inflammation/infection (median value), U = 626, z = -2.45, p = .014.
Thirty one (31) patients comprising 34.4% of the study population were identified to have IDA. The logistic regression model was not statistically significant, χ2(4) = 3.965, p = .138. Hence, our data suggests that chr cannot be used as a predictor of iron deficiency state in dialysis patients.