الفهرس 
Androgenetic Alopecia
LipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosis Lipodermatosclerosis LipodermatosclerosisLipodermatosclerosisLipodermatosclerosisLipodermatosclerosisOnly 14 pages are availabe for public view
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Abstract
Androgenetic alopecia (AGA) is the most common pattern of scalp hair loss in both men and women. It results from shortening of the anagen phase of the hair cycle and subsequently, miniaturization of hair follicles.
This disease is important because of the intense emo¬tional distress, it causes by disrupting self image leading to overwhelming effects on the patient’s quality of life.
Diagnosis and therapy of hair and scalp diseases were in the last years subject to significant progress. One of the major developments was employing imaging techniques, including hair and scalp folliscope. Although Folliscope is one of the non-invasive imaging techniques, it allows the visualization of hair at high magnification and the measurement of relevant trichologic structures.
Platelet-rich plasma is defined as autologous blood with a concentration of platelets above baseline values. Growth factors released by platelets recruit reparative cells and may augment wound healing. It has been found to be beneficial in dermatology, for example in acne scarring, wound healing and fat transplantation. It has also been shown to promote hair survival and growth, both in vitro and in vivo.
PRP increases the proliferation of dermal papillae cells and activates extracellular signal-regulated kinases (ERK) and phosphatidylinositol 3′-kinase (PI3K) / Akt signaling pathways. Additionally, fibroblast growth factor-7 and beta catenin, which are both stimulators of hair follicle growth, were stimulated after PRP administration.
Our study aimed to evaluate the efficacy of autologous PRP in the treatment of androgenetic alopecia. The study recruited a total of 40 female patients with pattern hair loss. All were subjected to detailed history taking and examination. Blood samples were taken from all subjects to assess hormonal parameters, and pelviabdominal U/S was done to all of them.
The patients were subjected to folliscopic examination, clinical assessment by 2 doctors, one nurse and a patient’s relative. The obtained data were tabulated and statistically analyzed. Our results showed a statistically significant increase in hair caliber in PRP treated cases compared to saline injected controls. In addition, the cases had a higher mean terminal density after treatment compared to controls but with insignificant difference.
Many controlled clinical trials are under way, but clinical use should be approached cautiously until high-level clinical evidence supporting platelet-rich plasma efficacy is available.