الفهرس 
CHAPTER 1Only 14 pages are availabe for public view
 |  | from | 16 |  |  |
| | | from | 16 | | |
Abstract
Neopterin is a compound act as a mediator in the biosynthesis of tetrahydrobiopterin which represent an essential cofactor of the mono-oxygenases involved in the neurotransmitter synthesis. Neopterin is produced by human monocytes and macrophages following induction by supernatant from activated T-lymphocytes or by other lymphokines and activated agents.
This study was carried out on 56 children. They were classified as follows:
Group/a:
Comprised of 10 cases with acute viral hepatitis post virus (A).
Grouplh:
Consisted of 10 cases with acute viral hepatitis post virus (A) after treatment (The same cases of group Ia). Group//:
Consisted of 16 cases of chronic active hepatitis post virus (B).
Group///:
Consisted of 10 cases of simple bilharzia!cases.
Group IV:
Consisted of 10 cases of complicated bilharzia! cases.
Group V:
Consisted of 10 cases ofthal ssaemia major.
Group VI:
Consisted of 10 healthy children as a control group.
All cases in this study were subjected to the following:
-Urine and stool analysis.
-Complete blood picture.
-Full clinical examination.
-Liver function tests.
-Serum neopterin level.
-Haemoglobin electrephoresis for cases of group V.
-Liver biopsies in some cases of group II.
The results of the present study denoted that haematological change; liver function and serum levels of neopterin were present in most of all cases and partial improvement in cases of group lb.