الفهرس 
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Abstract
Chemerin is an adipokine that regulates adipogenesis and
adipocyte metabolism. It may mediate a link between obesity, inflammation, insulin resistance, type
2 diabetes mellitus and cardiovascular disease. The aim of the present work is to investigate the
causal relationship between serum chemerin, insulin resistance and inflammatory markers in lean and
obese type II Egyptian diabetics.
This study included 120 subjects, classified into the following groups (each thirty): GI: lean
controls, GII: lean diabetics, GIII: Obese controls and GIV: Obese diabetics.
The following biochemical parameters were estimated in this study: serum chemerin, fasting and
postprandial plasma glucose (FPG & PPPG), glycated hemoglobin (HbA1c), serum insulin, lipids
profile [total cholesterol (TC), triacylglycerols (TAGs), high density lipoprotein-cholesterol
(HDL-C) and low density lipoprotein-cholesterol (LDL-C)], as well as tumor necrosis factor-α
(TNF-α) and interleukin 6 (IL-6). In addition, body mass index (BMI), HOMA-IR (homeostasis model
assessment for insulin restistance) and HOMA-β (homeostasis model assessment of β-cell function)
were calculated and blood pressure was measured.
Results revealed that serum chemerin levels were significantly increased in lean and obese type 2
diabetic patients compared to their controls and in obese subjects compared with
lean normal controls. Chemerin showed higher results in obese
than lean subjects.
Serum chemerin levels were also positively correlated with age, BMI, FPG & PPPG, serum insulin,
HOMA-IR, TC, TAGs, LDL-C,TNF-α and IL-6. Moreover, a negative correlation was found between serum
chemerin level, HOMA-β and HDL-C. However, no significant correlation was observed between serum
chemerin levels and sex.
In conclusion, serum chemerin is associated with insulin resistance, inflammation and obesity
in type II Egyptian diabetics.