الفهرس 
Features of the Galectin Superfamily of ProteinsOnly 14 pages are availabe for public view
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Abstract
Acute myeloid leukemia (AML) is the most common type of leukemia in adults with the lowest survival rate of all the leukemias. It is a heterogeneous disease in which a variety of cytogenetic and molecular alterations have been identified. Some galectins were previously reported to have important roles in cancer like neoplastic transformation, tumor cell survival, angiogenesis and tumor metastasis. Previous studies showed that some galectin family members play a role in various types of leukemia. The present study aims at evaluating and clarifying the diagnostic and prognostic value of the expression of cancer related galectins in relation to the clinicopathological characters of AML patients. Quantitative real time polymerase chain reaction (qRT-PCR) was used to detect expression profile of eight galectin family members (galectin-1, -2, -3, -4, -8, -9, -12 and -13) in 53 newly diagnosed de novo AML patients.
Methods: Quantitative real time polymerase chain reaction (qRT-PCR) was used to detect expression profile of eight galectin family members (galectin 1, 2, 3, 4, 8, 9, 12 and 13) in 53 newly diagnosed de novo AML patients (the Cancer Institute (NCI), Cairo University (CU) and diagnosed between July 2012 to May 2013).
Results: Our results showed that patients with lower LGALS12 gene expression have a lower overall survival than those with higher expression (P-value < 0.026). Moreover, a statistically significant association between the LGALS4 gene expression and patient age is found. Hence, the higher expression of LGALS4 gene is associated with younger age (adjusted P-value < 0.001).