الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Hepatotoxicity is main problems worldwide. Thus, it is necessary to obtain pharmaceutical alternatives for liver diseases. This study was conducted to explore possible protective effect of methanolic leaves extract of Ficus carica on carbon tetrachloride CCl4-induced hepatotoxicity, haemotoxicity and oxidative stress in experimental animal models. Experimental hepatic damage was induced in methanolic extract by carbon tetrachloride (CCl4) administration (2.5 mg/kg,) orally every other day for 8 weeks. Methanolic extract of Ficus carica leaf (500 mg/kg,) was administered orally. Administration of CCl4 in untreated rats led to anemia, thrombocytopenia, and leucocytosis. CCl4 also led to significant increase in serum transaminases (ALT and AST), phosphatase (ALP) and lactic dehydrogenase (LDH) respectively compared with control animals. Also, CCl4produced significant (P<0.05) increase in serum cholesterol, triglycerides and LDL with significant decrease in HDL compared with normal rats. Furthermore, CCl4caused significant increase in the lipid peroxidation with decreased levels of SOD, CAT, GSH and glutathione indicating oxidative stress in the liver. Pre-treatment with Ficus carica leaf extract brought about significant restoration of the haematological parameters to values that were comparable to those of the control with concomitant decrease in the activities of ALT, AST and ALP. Similarly, serum levels of lipid fractions and protein contents were also brought to near normal by the Ficus extract. Ficus extract significantly reduced lipid peroxidation and augmented antioxidant level in liver when compared with the CCl4-intoxicated rats. In conclusion, it can be concluded that supplementing ficus extract can exert a hepatoprotective effect in rat model of CCl4-induced liver damage, which was attributed to the strong antioxidant power.