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Abstract Chronic kidney disease (CKD) is now being recognized worldwide as an important problem in children. The prevalence of CRF in pediatric population is 18 per million. Children constitute about 1–2% of total ESRD population but, devastating effects of ESRD in children are more significant than in adults. Gastrointestinal symptoms are quite common in children with CKD. Growth rate in these children is low due to insufficient food and calorie intake caused by GI problems. Upper GI disorders can lead to feeding problems, undernutrition and failure to thrive in children, so their importance in children is more than adults. H.pylori infection is considered one of the causal factors for these gastrointestinal symptoms. H. pylori infection is one of the most common chronic infections in humans. Infection with H. pylori has been implicated not only in the etiopathogenesis of gastrointestinal disease, such as gastritis, ulcerative diseases, low grade mucosa-associated lymphoid tissue lymphoma, and gastric malignancies, but also in various extra gastrointestinal conditions. Several studies have investigated gastric H. pylori infection in adult CKD patients, but scarce data exist regarding this issue in infancy and childhood. |