الفهرس 
Hair CycleOnly 14 pages are availabe for public view
 |  | from | 32 |  |  |
| | | from | 32 | | |
Abstract
Hair fall constitutes about 53% among general population, where female to male ratio is estimated to be around 1:3. Although hair provides no vital function for humans, hair affection has both psychological effects that influence the wellbeing of patient as well as an economic overload by its treatment. Many factors control the process of hair growth including hormonal, neural, genetic and growth factors beside the extrinsic factors.
Therapeutic trials for new treatment of hairfall are continuously performed but, no specific combinations or formulas are agreed upon among dermatologists.
Minoxidil injection intradermally was found to shorten telogen causing premature entry of resting hair follicles into anagen. It was found to cause elongation of anagen and increase hair follicle size and helps in normal epithelial function. On the other hand some studies proved that Placental extracts has substantial effect in the treatment of hair loss because it contains abundant growth factors and hormones such as vascular endothelial growth factor, epidermal growth factor, transforming growth factor and IGF that can accelerate cell proliferation on hair follicle and interfollicular cells. It found to play a role in protein and nucleic acid synthesis.
Minoxidil and placenta are injected into scalp to insure delivery around the hair follicle, but now nanotechnology offers a brand new efficient drug delivery system that can be utilized mostly in the delivery of all hair growth promoters targeting effectively hair follicles and shafts. This is achieved through constructing structures in the nanoscale range or smaller that carry the drug.
In this comparative study 30 male guinea pigs were divided into 3 groups, each group contains 10 guinea pigs in which:
group A: injected by placental extract.
group B: injected by minoxidil 5%.
group C: injected by combined injection (placental extract and minoxidil 5%) for comparison of caliber, density and Anagen to Telogen hair ratio.
Injections were done every 2 week for 10 weeks.
The three groups of guinea pigs showed clinical improvement on hair growth regarding caliber, density and anagen to telogen hairs ratio which showed statistical high significance. Most in combined treatment of both materials (minoxidil 5% and placental extract solution).
In conclusion, hair therapy is still an open area for many studies and research. Therapeutic modalities based on molecular understanding of hair follicle biology and the knowledge of changing milieus of hair follicle regarding cytokines and hair growth promoters and the trial to decrease hair growth suppressor cytokines and genes is the key to answer questions regarding diseases affecting hair growth and their therapies.
Combined therapies using minoxidil, placental extracts and other hair promoters should be used on individual bases according to each and every patient based on their needs according to stages of hair loss and their laboratory results.
Many studies regarding hair biology and effect of different combinations with larger number of candidates on animals or humans should be done to reach solid grounds on hair treatment strategies.