الفهرس 
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Abstract
This work was undertaken to study the histological and the ultra-structural changes that occurred in the myocardium (left ventricles and right atria) of adult male albino rats after intra-peritoneal injection of cadmium chloride and to study the possible protective effect of zinc chloride on these changes. Sixty adult male albino rats weighting 200-230 gm were used in this study. The animals were divided into five groups (twelve rats each group): -group A (Control group): The rats received 1cc of distilled water daily by intra-peritoneal injection. -group B (Cadmium-treated group): The rats of this group were injected intra- peritoneally daily with cadmium chloride. -group C (Cadmium & Zinc treated group): The animals were injected daily with cadmium chloride and zinc chloride by intra-peritoneal route. -group D: as group (C), but the animals were pre-treated before the experiment for one week with zinc chloride. -group E (Zinc treated group): The rats were injected intra- peritoneally daily with ZnCl2. The duration of the experiment was 45 days. After (one week, two weeks, four weeks and six weeks) from the beginning of the experiment, The chest was opened and the hearts were dissected and prepared for studying the microscopic structure of the myocardium of left ventricles and right atria by the light and electron microscopic examination. Statistical analysis was done to study the transverse diameter of the cardiac muscle fibers and was also done to study the amount of glycogen in the cardiac muscle fibers. Results revealed that cadmium has a negative effect on the cardiac muscle appeared in the form of destruction of the cardiac muscle fibers in focal areas accompanied with cellular infiltration with mononuclear inflammatory cells. Zinc reduced these changes particularly in the first weeks of the experiment.