الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Breast cancer is a major health problem that warranted efforts to be paid in order to increase the diagnostic capability of the routinely used diagnostic aids.
The aim in this study was to evaluate accuracy of proton MR spectroscopy to differentiate between benign and malignant breast lesions, we aimed also to assess the diagnostic accuracy of the combined three parameters (dynamic contrast enhanced MRI, diffusion weighted imaging DWI, and proton magnetic resonance spectroscopy MRS) in increase specificity of MRI in comparison to single parameter dynamic contrast enhanced MRI.
One hundred female patients were enrolled in this prospective study from October 2012 to June 2015. Statistical tests were performed to check for sensitivity, specificity, accuracy and predictive values for each parameter and for combined parameters
All patients underwent MRI examination with DCE-MRI, DWI, and 1H MRS with classification of their findings according to Breast imaging reporting and Data System. The findings of each parameter and MP-MRI were correlated with histopathological results.
Dynamic contrast enhanced MRI had sensitivity 89.8%, specificity 74.1%, and accuracy 85%.
Diffusion weighted imaging had sensitivity 97%, specificity 54.8% and accuracy 84%.
Proton MR Spectroscopy had sensitivity 73.5%, specificity 80% and accuracy 74%.
We found that single voxel spectroscopy was not powerful tool in characterizing benign and malignant breast lesions.
Multi-parametric MRI with 3 parameters, yielded the highest specificity (93.55%) compared to DCE-MRI (74%), also accuracy was highest for MP-MRI (95%), compared to each parameter.
In conclusion, MP-MRI with 3 parameters (DCE-MRI, DWI, and 1H MRS) has a greater diagnostic accuracy for breast cancer diagnosis than DCE-MRI alone.