الفهرس 
EpilepsyOnly 14 pages are availabe for public view
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Abstract
Objective : this study aims to examine the effect of valproate and carbamazepine monotherapy or
polytherapy on bone mineral density in epileptic children.
Methods : axial bone mineral density (L2-L4) was measured by dual-energy x-ray absorptiometry in 30
children with idiopathic epilepsy (patients group) and 12 healthy children (control group) of the
same coh01t as the patients group. The epileptic children treated with either valproate monotherapy
(n=14) or carbamazepine monotherapy (n=8) or both drugs as polytherapy (n=8) for more than one
year. Serum level of 25(0H)D3, Ca, P and alkaline phospharase were also measured.
Results : the results of this study showed that the patients group had a highly statistically
significant reduction in bone mineral density. This reduction increased with the increase duration
of the therapy. Valproate monotherapy reduced BMD in 7 patient (4 osteopenic and 3 osteoprotic),
while carbamazepine monotherapy reduced BMD in I patient (osteoprotic). Polytherapy reduced BMD in
5 patients (4 osteopenic and I osteoprotic ). There were a highly statistically significant
decrease in serum level of 25(0H)D3; statistically significant decrease in serum level of P and a
statistically significant increase in serum level of alkaline phosphatase in patients group.
Conclusion : it is concluded that valproate and carbamazepine either in monotherapy or polytherapy
reduce axial bone mineral density in children with idiopathic epilepsy and may increase their
risk of osteoporotic fractures.