الفهرس 
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Abstract
The thesis aim at preparing and classifling some new oxime
compounds and their metal complexes, so as to discover some effective
components, which will be used as anti-tumor and antimicrobial diseases.
First part of our study will be beginning by preparing guanidine oxime
complex which is produced from condensation of oxime and aromatic
amine .
The thesis is composed of three main chapter in addition to Arabic and
English summary along with scientific reference related to the thesis
The first chapter:
- introduction
In this chapter, a literature survey was carried out and included the
following of items:-
a) Introduction about importance of oximes and Schiff bases.
b) Importance of oximes and modes of bonding of oxime in metal
complexes.
c) Definition, nomenclature and preparation of oximes and Schiff
bases.
d) Importance of oximes and schiff bases and their metal complexes
in the following fields of applications:-
1- Biological application: -Antitumor, anti-mycobacterial and
antimicrobial activity.
- Review of literatureonoximes and schiff bases.
Formation of schiff bases and classified as bidnetate and
bis-bidentate Schiff bases.
The second chapter: Experimental
In this chapter, the methods used for the preparation of new oxime
ligand4,4\((bis(phenylamino)methylene)bis(azoanylylidene)bis(hydroxyi
mino)pentan-2-one ligand(H2L), (1) and preparation of its metal
complexes for copper(II), nickel(II), cobalt(II), manganese(II),
zinc(II),zerconyl(II),and mercury(I1) .
The techniques used for characterization of new ligand and its complexes
were also described which included: elemental, thermal analyses, infrared
spectra, proton magnetic resonance (’H-NMR), mass spectra, electronic
absorption spectra (UV-VIS), electron spin resonance (ESR), magnetic
also described biological activity of the oxime ligand and its metal
complexes and determine The cytotoxic activity of the ligands and its
complexes against cell lines of cancers cell and the invitro cytotoxicity
properties against Gram positive bacterium (Bacillus subtilis), Gram
negative bacterium (Escherichia coli).
The third chapter:- Results and discussion
The analytical and spectral studies showed that the ligand
4,4\((bis(phenylamino)methylene)bis(azoanylylidene)bis(hydroxyimino)p
entan-2-one ligand(H2L)behaves as neutral tridentate ligand.
The second, the ligand behaves as monobasic tridentate.
The last mode, the ligand behaves as monobasic tetra dentate ligand
Complexes proved that they have biological activity as anti-tumor and it
was found that Cu complex (2) and Hg complex (16) gave effective
results against human breast MCF-7 cancer cell line and also Zn complex
(8) gave effective result against human liver HEPG-2 cancer cell line and
also results proved that complexes have biological activity as anti
bacteria and found that Hg complex (1 6), Co complex (10) and Zn
complex (7) gave effective results against different types of bacteria.