الفهرس 
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Abstract
This experimental study aimed to evaluate the wound healing activity of five human topical medicaments in wounds of distal limbs in donkeys. This study was carried out on thirty six clinically healthy adult donkeys. All the donkeys were dewormed and were received antitetanic serum. They were randomly divided into six groups according to the type of treatment, each group of six donkeys.
Food was withheld from donkeys for 12 hours before surgery. Donkeys were tranquilized by intravenous administration of xylazine (1.1 mg/kg) and were anesthetized by intravenous administration of Ketamin (2.2 mg/kg). Surgically created a 2x2 cm full-thickness skin wound on the dorsal aspect of the metacarpal region medial to the common digital extensor tendon in the two forelimbs of each animal. Medicaments were applied to the experimental wounds assigned to them as follow:-
First group: Healosol spray® (phenytoin 2%).
Second group: Panthenol gel® (D. panthenol 5%).
Third group: MEBO ointment® (ß-sitosterol 0.25%).
Fourth group: Iruxol ointment® (collagenase Clostridiopeptidase).
Fifth group: Helarium cream® (honey, propolis, zinc oxide and chamomile)
Sixth group: Sterile distilled water (control group).
At week intervals wounds healing activity was assessed by gross observation, geometric assessment and histopathological evaluation of wound healing and after statistical analysis the results revealed that:-
The wound contraction and wound healing percentages with Healosol group were significantly higher than other groups from the first week of treatment until the complete healing of wound. The greater contribution of contraction to wound healing in Healosol group compared with other groups results in a small healthy scar is left which give good cosmetic appearance, moreover Healosol was the most efficient as it cut down the duration of wound healing to six weeks only. Suggest its use as an effective and low cost wound healing promoting agent for full thickness skin wounds in equine.
Although Panthenol treated wounds showed epithelialization later than Phenytoin and Helarium groups, the progress of epithelialization in Panthenol group was highly significant than other groups and by the end of 7th week all Panthenol treated wounds have completely healed and the relative contribution of epithelialization to wound closure was highly significant than other groups result in the largest area of newly formed inferior quality epithelium and, subsequently, more pronounced scar. The resultant blemish might compromise the animal economic value.
Helarium is combination drug and it was found to significantly accelerate wound contraction and improve wound epithelialization, but the complete healing delayed for the 8th week and this may related to the compounds interaction mechanisms that act on different stages of wound healing, providing diverse actions throughout the wound healing, this may lead to a different outputs in terms of hyper granulation tissue formation in some wounds and retardation in the overall time to wound healing than Helarium and Panthenol groups.
Mebo and Iruxol did not have a significant effect on wound contraction compared to other treated groups and secondly did not improve epithelialization compared to other treated and control groups, so that Mebo and Iruxol were found to significantly retard the overall wound healing rates and the overall time to wound healing.