الفهرس 
Chronic kidney diseaseOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is a chronic disease that affects 366 million people worldwide. Diabetes results in both microvascular and macrovascular complications. The primary microvascular complications of diabetes include damage kidneys known as diabetic nephropathy (DN), is the most common complication of diabetes.
Laminin is a 900-kDa glycoprotein that is a normal component of basement membranes. It is considered that serum laminin cannot be filtered in the normal glomerulus, and the urinary laminin is derived from the kidneys. It has been shown by immunohistochemistry that laminin is located in the mesangial expansion and thickened capillary basement membranes characteristic of diabetic nephropathy.
The present work is a case controlled study conducted on 60 patients admitted to the outpatients and inpatients clinics of the Department of Internal Medicine, Menoufia University Hospitals. 20 healthy individuals were also included as a control group during the period from March, 2015 to July, 2015 to determine the values of measurement of urinary laminin as a marker for early diagnosis of diabetic nephropathy in patients with type-2 diabetes.