الفهرس 
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Abstract
The current study included 76 subjects; 50 females diagnosed as SLE according to ACR criteria 1982 (≥ 4 criteria at time of diagnosis) as study group with age range 15 to 63 years and 26 apparently healthy females as control group with age range 19 to 60 years .All subjects were informed about the aim of the study and gave their consent. Patients were recruited from outpatient clinic, rheumatology unit, Assiut University Hospitals.
► SLE patients were classified according to the presence or absence of ACR criteria for LN into SLE patients without nephritis (17 patients) and LN patients (33 patients).
The following were done:
1- Medical history and clinical examination:
-Complete history taking and clinical examination to assess clinical signs and symptoms of lupus and disease status.
-SLE activity was assessed according to SLEDAI 2k.
2-Laboratory investigations:
1-Complete blood countandreticulocytic count.
2- Direct Coombs’ test.
3-ESR.
4- Serum albumin, urea ,creatinine, calcium and phosphorus.
5-Creatinine clearance.
6-Urine analysis.
7- 24 hour protein in urine.
8-CRP.
9-ANA.
10-Anti-ds DNA.
11-Complement (C3 and C4).
12-Serum vitamin D level.
The current study showed the following findings:
There wasno differencein the distribution of vitamin D status between SLE patients and control subjects and between SLE .As vitamin D deficiency was frequently seen in control subjects as well as SLE patients.
There was no significant difference in distribution of vitamin D in relation to time after SLE diagnosis.There was no significant difference in vitamin D level between SLE patients with and without fatigue and SLE patients with or without photosensitivity.There was significant increase in serum calcium in SLE patients with vitamin D level >20ng/ml when compared to those with vitamin D level ≤ 20ng/ml.
There was a negative correlation between vitamin D level and anti-ds DNA level in SLE patients.There was a positive correlation between vitamin D level and complement (C3) level in SLE patients .There was a non significant weak positive correlation between vitamin D level and complement (C4) level in SLE patients.There was non significant correlation between vitamin D level and ESR (first hour) in SLE patients.There was no consistent significant association of positive CRP test results with vitamin D deficiency in SLE patients.There was negative correlation between vitamin D level and SLEDAI-2K score.